2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Malate Dehydrogenase (MDH)

Malate Dehydrogenase (MDH)

Malate Dehydrogenase

Malate Dehydrogenase (MDH) is an enzyme that plays a key role in cellular metabolism and belongs to the NAD-dependent dehydrogenase family. Malate Dehydrogenase (MDH) catalyzes the reversible conversion between malate and oxaloacetate. There are multiple subtypes of MDH. In eukaryotes, there are mainly cytoplasmic MDH1, mitochondrial MDH2, and MDH present in peroxisomes, glyoxysomes, and chloroplasts; there is only one MDH in prokaryotes such as Escherichia coli. MDH1 is closely related to the proliferation and survival of tumor cells, and its high expression is associated with a poor prognosis of non-small cell lung cancer. MDH1 plays an important role in replenishing cytoplasmic NAD to support glycolysis during cell proliferation, and together with lactate dehydrogenase (LDH), maintains the intracellular NAD supply; in cardiovascular disease research, it was found that changes in its activity are related to energy metabolism, oxidative stress and other processes in cardiac tissue. In addition, MDH participates in important metabolic pathways such as the tricarboxylic acid cycle, gluconeogenesis, and amino acid synthesis, and plays a role in different cellular compartments. For example, MDH transports reducing equivalents between the cytoplasm and mitochondria through the malate-aspartate shuttle, maintaining cellular energy metabolism and normal physiological functions[1][2][3][4][5][6].

Malate Dehydrogenase (MDH) Related Products (8):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147791
    MDH1-IN-2
    		Inhibitor 98.70%
    MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis.
    MDH1-IN-2
  • HY-147790
    MDH1-IN-1
    		Inhibitor 99.97%
    MDH1-IN-1 (Compound 5i) is a potent inhibitor of MDH1 with an IC50 of 6.79 μM. MDH1-IN-1 has the potential for the research of cancer diseases.
    MDH1-IN-1
  • HY-W613220
    MDH1/2-IN-1
    		Inhibitor 99.53%
    MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 μM and 1.06 μM respectively). MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism.
    MDH1/2-IN-1
  • HY-P3001A
    Malate Dehydrogenase,Yeast
    Malate dehydrogenase, Yeast (EC 1.1.1.37) is an enzyme in the citric acid cycle that catalyzes the conversion of malate to oxaloacetate (requiring NAD+). Malate dehydrogenase participates in gluconeogenesis, the process of synthesizing glucose from small molecules.
    Malate Dehydrogenase,Yeast
  • HY-P2809B
    Malic Dehydrogenase, Porcine
    Malic Dehydrogenase, Porcine (EC 1.1.1.37) exists as two isoforms within eukaryotic cells, one that is expressed in the mitochondria and functions in the TCA cycle and one in the cytoplasm that converts malate from the mitochondria back into oxaloacetate.
    Malic Dehydrogenase, Porcine
  • HY-P2809A
    Malic Dehydrogenase, Thermus flavus
    Malic Dehydrogenase, Thermus flavus (EC 1.1.1.37) exists as two isoforms within eukaryotic cells, one that is expressed in the mitochondria and functions in the TCA cycle and one in the cytoplasm that converts malate from the mitochondria back into oxaloacetate.
    Malic Dehydrogenase, Thermus flavus
  • HY-P3001B
    Malate Dehydrogenase, Porcine
    Malate dehydrogenase, Porcine, is a dehydrogenase that catalyzes the conversion of malate to oxaloacetate.
    Malate Dehydrogenase, Porcine
  • HY-181604
    MDH2-IN-2
    		Inhibitor
    MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 μM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of Caenorhabditis elegans. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research.
    MDH2-IN-2